RESEARCH FIELD

NEWS

Marco Bonelli added a new publication (10/03/2019)

Show me

Magda Zanzottera added a new publication (10/03/2019)

Show me

Marco Ferrari added a new publication (08/04/2019)

Show me

UPCOMING SEMINARS

    June 17, 2019

  • Seminar by Jack Tuszynski, entitled: 100 Years from Quantum Physics to Quantum Biology . How Long to Quantum Medicine?

RESEARCH AREA: Biology, Medicine, Agricultural and Veterinary Sciences

Contact person

Members

PhD Students

By Ibrahim Barakat (Own work), via Wikimedia Commons

Research interests

Primary interest of the present unit is to study the mechanism of action of toxic substances at molecular level and its relevance for human risk assessment. Different areas of toxicological relevance are pursued:

  • Immunotoxicology
    the primary focus: alternative testing to animal models; understanding the mechanism of action of immunotoxic/immunomodulatory compounds; defining the role of RACK-1 and protein kinase C in immunosenescence, identify compounds able to reverse such changes.
  • Neurotoxicology
    In vitro evaluation of the molecular mechanisms involved in neuronal damage and dysfunction. Focus on: ionic channels, calcium homeostasis, phosphorylation pathways, trancription factors, inflammatory response.
  • Developmental Toxicology
    In vitro (rodent whole embryo culture, Amphibian developmental assays) and in vivo (in utero exposure of rodent embryos) evaluation of the mechanisms and pathogenic pathways involved in teratogenic events. Evaluation of effects of mixtures of compounds on embryo development.
  • Genotoxicity
    In vitro evaluation of the interaction of chemicals with DNA.
  • Risk characterization
    Focused on hazard characterization, the qualitative and/or quantitative evaluation of the nature of the adverse effects associate with chemicals and the evaluation of human exposure

ERC panel descriptors

LS7_5 Toxicology
LS3_7 Cell signaling and cellular interactions

Back