RESEARCH AREA: Biology, Medicine, Agricultural and Veterinary Sciences
- Silvia Fustinoni (firstname.lastname@example.org)
- Luca Boniardi (Cycle: XXXII)
The area explores the relationship between the environment and health, using a molecular epidemiology approach. Exposure to toxicants/pollutants may trigger several responses in challenged human body, that may be detected and applied as biomarkers. Among them it is possible to measure the presence of the pollutants, their metabolites, and early biological effects, such as: oxidative stress markers and epigenetic markers (DNA methylation, histone modifications, microRNAs). These may be measured in easily accessible biological samples, such as peripheral blood, urine, saliva, hair.
Given the need to evaluate tiny exposures and subtitle effects, a large number of subjects needs to be investigated and a sophisticated statistical analysis of biological data is required.
Research lines include:
- air pollution and epigenetic changes;
- solid waste incinerator emissions and biomarkers of exposure;
- health status, epigenetic changes and susceptibility to environmental pollutants;
- hair as a matrix to evaluate cumulative exposure.
Lab techniques include, for toxicology: liquid chromatography and mass spectrometry, ICP/MS, GC/MS; for molecular epidemiology and epigenetics: DNA and RNA extraction, PCR, Pyrosequencing, Real time PCR, Open array, flow cytometry, cell coltures.
ERC panel descriptorsLS7_5 Toxicology
LS7_11 Environment and health risks including radiation
LS7_12 Occupational medicine