NEWS

New PhD coordinator

On May 31st, 2019 professor Francesco Ficetola was elected as the new coordinator of the PhD course in Environmental Sciences.

Congratulations and best of luck!

Filippo Brandolini added a new publication (02/07/2019)

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Mattia Falaschi added a new publication (29/07/2019)

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Camilla Carla Parenti added a new publication (17/08/2019)

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UPCOMING SEMINARS

    September 2, 2019

  • Seminar by Dott.ssa Beata Siemiatkowska, entitled: Redox regulation analysis by mass spectrometry”

Environmental contaminants and human risk assessment

Contact person

Members

PhD Students

By Ibrahim Barakat (Own work), via Wikimedia Commons

Research interests

Primary interest of the present unit is to study the mechanism of action of toxic substances at molecular level and its relevance for human risk assessment. Different areas of toxicological relevance are pursued:

  • Immunotoxicology
    the primary focus: alternative testing to animal models; understanding the mechanism of action of immunotoxic/immunomodulatory compounds; defining the role of RACK-1 and protein kinase C in immunosenescence, identify compounds able to reverse such changes.
  • Neurotoxicology
    In vitro evaluation of the molecular mechanisms involved in neuronal damage and dysfunction. Focus on: ionic channels, calcium homeostasis, phosphorylation pathways, trancription factors, inflammatory response.
  • Developmental Toxicology
    In vitro (rodent whole embryo culture, Amphibian developmental assays) and in vivo (in utero exposure of rodent embryos) evaluation of the mechanisms and pathogenic pathways involved in teratogenic events. Evaluation of effects of mixtures of compounds on embryo development.
  • Genotoxicity
    In vitro evaluation of the interaction of chemicals with DNA.
  • Risk characterization 
    Focused on hazard characterization, the qualitative and/or quantitative evaluation of the nature of the adverse effects associate with chemicals and the evaluation of human exposure

ERC panel descriptors

LS7_5 Toxicology
LS3_7 Cell signaling and cellular interactions

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