Environmental contaminants and human risk assessment
- Emanuela Corsini (firstname.lastname@example.org)
Primary interest of the present unit is to study the mechanism of action of toxic substances at molecular level and its relevance for human risk assessment. Different areas of toxicological relevance are pursued:
the primary focus: alternative testing to animal models; understanding the mechanism of action of immunotoxic/immunomodulatory compounds; defining the role of RACK-1 and protein kinase C in immunosenescence, identify compounds able to reverse such changes.
In vitro evaluation of the molecular mechanisms involved in neuronal damage and dysfunction. Focus on: ionic channels, calcium homeostasis, phosphorylation pathways, trancription factors, inflammatory response.
- Developmental Toxicology
In vitro (rodent whole embryo culture, Amphibian developmental assays) and in vivo (in utero exposure of rodent embryos) evaluation of the mechanisms and pathogenic pathways involved in teratogenic events. Evaluation of effects of mixtures of compounds on embryo development.
In vitro evaluation of the interaction of chemicals with DNA.
- Risk characterization
Focused on hazard characterization, the qualitative and/or quantitative evaluation of the nature of the adverse effects associate with chemicals and the evaluation of human exposure
ERC panel descriptorsLS7_5 Toxicology
LS3_7 Cell signaling and cellular interactions